Assistant Laboratory Animal Technician (ALAT) Practice Exam

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True or False: The "F1" on the end of a hybrid mouse designation indicates this is the second generation.

  1. True

  2. False

  3. Indicates it is a knockout strain

  4. Indicates it is a wild type

The correct answer is: False

The designation "F1" in hybrid mouse nomenclature is significant because it refers to the first filial generation, which is the first generation of offspring resulting from the mating of two different parental strains. In genetics, the F1 generation is the immediate offspring of the parental generation (P), while the subsequent generation, resulting from mating F1 individuals, is referred to as F2. Therefore, "F1" indicates that it is the first generation of hybrids produced from two distinct parent strains, making the statement false. In this context, the understanding of nomenclature is crucial for researchers, as it helps in tracking genetic lineage and understanding breeding outcomes in laboratory settings. The other choices do not provide an accurate definition or function associated with the F1 designation.